Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR.

ABSTRACT:

Background

Multimorbidities are a global health challenge. Accumulating evidence indicates that overlapping genetic architectures underlie comorbid complex human traits and disorders. This can be quantified for a pair of phenotypes using various techniques. Still, the pattern of genetic overlap between three distinct complex phenotypes, which is important for understanding multimorbidities, has not been possible to quantify.

Methods

Here, we present and validate the novel trivariate MiXeR tool, which disentangles the pattern of genetic overlap between three complex phenotypes using summary statistics from genome-wide association studies. Our simulations show that trivariate MiXeR can reliably reconstruct different patterns of genetic overlap and estimate the proportions of g

SUBMITTER: Shadrin AA 

PROVIDER: S-EPMC12482798 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature