Sertraline and inflammatory markers in major depression: a systematic review and meta-analysis.

ABSTRACT:

Background

Increasing evidence suggests a link between major depressive disorder (MDD) and inflammatory pathways. Sertraline, a commonly used selective serotonin reuptake inhibitor (SSRI), may influence inflammatory cytokine levels. This systematic review and meta-analysis aimed to elucidate the association between the antidepressant sertraline and inflammatory processes and to delineate the roles of key cytokines within this context.

Methods

Electronic searches of the Web of Science, MEDLINE, and Embase databases (from inception to August 8, 2025) yielded 890 unique records. The included studies measured serum concentrations of inflammatory cytokines in patients with major depressive disorder (MDD) before and after sertraline treatment, with subsequent analysis of the effec

SUBMITTER: Xie Z 

PROVIDER: S-EPMC12482824 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature