Exploring safety of down-titrating diuretics in heart failure management.

ABSTRACT:

Aims

Loop diuretics are widely used in heart failure (HF) for symptom relief. Guidelines advise treating patients with the lowest possible dose of loop diuretics to maintain euvolaemia, based on expert opinion only. However, data on the safety of this practice are scarce. This analysis aims to investigate the clinical course after changing loop diuretics in stable HF patients.

Methods and results

A post-hoc analysis from the TIME-CHF study was conducted in 622 patients. Daily loop diuretic doses were meticulously recorded, resulting in 11 035 dose evaluations assessed. The frequency of relevant events within 30 days (hospitalization, death, dose change) following an up-titration, down-titration, or no change in diuretic therapy was calculated. Risk of hospitalization and dea

SUBMITTER: Geraeds CBG 

PROVIDER: S-EPMC12482844 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature