Evaluating the clinico-pathological features including the immunohistochemical and molecular landscape of synovial sarcoma cases from a tertiary care cancer referral centre in India.

ABSTRACT:

Background

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial differentiation, with a propensity to occur in young adults. The pathognomonic t(X;18) chromosomal translocation and subsequent development of the SS18:SSX fusion oncogenes are the driver of the distinct genomic features.

Aim

To study the Clinicopathological, immunohistochemical and molecular features of SS occurring in all the organ systems.

Method

A retrospective observational study was conducted over a period of 4 years at a tertiary cancer centre.

Result

One hundred eight patients were included in the study based on exclusion and inclusion criteria. The median age of patients was 30.5 years and mean tumor diameter was 10.5 cm. Most common site was lower limb follow

SUBMITTER: Rai H 

PROVIDER: S-EPMC12482858 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature