Cutavirus Infection in Large-Plaque Parapsoriasis, a Premalignant Condition of Mycosis Fungoides.

ABSTRACT:

Background

Cutavirus (CuV) is associated with mycosis fungoides; however, the CuV status in parapsoriasis en plaques (PP), a premalignant inflammatory condition of mycosis fungoides, has not been fully delineated.

Methods

Fifty-five Japanese patients with chronic inflammatory skin diseases, including 13 patients with PP, were studied.

Results

CuV DNA was detected significantly more frequently in biopsies of the lesional skin from patients with PP (38%; 4 of 13) than in those from patients with other inflammatory skin diseases (2%; 1 of 42; P = .009). All CuV-positive PP cases were of the large-plaque parapsoriasis (LPP) subtype. The viral loads ranged from 83 450 to 2 164 170 copies/103 cells. We recovered near-full-length CuV sequences from the CuV-positive LPP biops

SUBMITTER: Hashida Y 

PROVIDER: S-EPMC12483076 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature