A mitochondria-targeted aggregation-induced emission photosensitizer for eradication <i>Candida</i> biofilms and treating oral ulcer.

ABSTRACT: With increasing drug resistance, Candida infections have posed serious threats to public health. Photodynamic therapy harnesses light to destroy pathomycete, providing a smart strategy for combating of Candida infections. However, due to lack of organelle targeting ability and bad extracellular polymeric substances penetrability, current photosensitizers (PSs) are far from desirable to clean biofilms and fight against drug resistance. Herein, a mitochondrion targeting aggregation-induced emission PS, LIQ-TPA-TZ, was developed for the efficient photodynamic treatment of oral Candida infection. LIQ-TPA-TZ has good singlet oxygen and hydroxyl radical generation ability, which can efficiently kill the Candida guilliermondii (C. guilliermondii) and eradicate t

SUBMITTER: Liu KM 

PROVIDER: S-EPMC12483137 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature