Reward anticipation-related neural activation following cued reinforcement in adults with psychotic psychopathology and biological relatives.

ABSTRACT:

Background

Schizophrenia is associated with hypoactivation of reward sensitive brain areas during reward anticipation. However, it is unclear whether these neural functions are similarly impaired in other disorders with psychotic symptomatology or individuals with genetic liability for psychosis. If abnormalities in reward sensitive brain areas are shared across individuals with psychotic psychopathology and people with heightened genetic liability for psychosis, there may be a common neural basis for symptoms of diminished pleasure and motivation.

Methods

We compared performance and neural activity in 123 people with a history of psychosis (PwP), 81 of their first-degree biological relatives, and 49 controls during a modified Monetary Incentive Delay task during fMRI.

Re

SUBMITTER: Demro C 

PROVIDER: S-EPMC12483191 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature