Associations of SARS-CoV-2 PCR positivity with clinical symptoms and race/ethnicity: The household transmission study.

ABSTRACT:

Objective

The objective of this study was to identify demographic and clinical factors associated with SARS-CoV-2 infection among household contacts (HCs) following exposure to a confirmed case.

Methods

We analyzed an existing case-ascertained prospective cohort study of 43 HCs of SARS-CoV-2-positive index cases recruited from Stanford Health Care between March 2020 and June 2022. Participants self-collected nasal swabs daily for up to 21 days for reverse transcription polymerase chain reaction (RT-PCR) testing and reported symptoms in daily diaries. Using Cox proportional hazards models, we assessed associations between participant characteristics over time to first positive PCR result.

Results

We found that symptomatology and race/ethnicity were independently associ

SUBMITTER: Goodman SH 

PROVIDER: S-EPMC12483199 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature