Pharmacokinetic profile of oral firocoxib in the koala (Phascolarctos cinereus).

ABSTRACT: The pharmacokinetic profile of firocoxib administered orally at 5 mg/kg as a single dose to three mature koalas of each sex is described. After single dose administration, the harmonic means for maximal plasma concentration (Cmax), time to reach Cmax (Tmax) and elimination half-life (t1/2) were 79.2 ng/mL, 3.69 h, and 5.01 h, respectively. Males exhibited a higher Cmax than females (217.4 vs 48.4 ng/mL), suggesting greater oral absorption, while females had a slower elimination (t1/2: 5.87 h vs 4.38 h in males), however these sex differences were not significant. After a wash-out period, the same dose was administered every 12 h, on six occasions to the same koalas. With repeat dosing, females had higher trough concentrations at 24 and 48 h, and 12 h after the last dose, compared to the ma

SUBMITTER: Shapiro AJ 

PROVIDER: S-EPMC12483202 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature