Cerenkov luminescence imaging and flexible autoradiography for specimen margin assessment during breast-conserving cancer surgery.

ABSTRACT:

Background

Among women with breast cancer who undergo breast-conserving surgery (BCS), 20% to 25% require further surgery because of close or involved margins. Improved techniques are needed to assess resection margins.

Purpose

The study aims were to assess the feasibility of the combined techniques of Cerenkov luminescence imaging-flexible autoradiography (CLI-FAR) to assess excision specimen margins in women undergoing BCS and to determine the diagnostic performance of intraoperative CLI-FAR imaging with postoperative histopathology as the reference standard.

Materials and methods

Women undergoing BCS were recruited prospectively at a single center over 13 months. Patients were injected with 250 MBq ± 10 MBq of 18F-fluorodeoxyglucose, 145 minutes before surgery; the

SUBMITTER: Sinha A 

PROVIDER: S-EPMC12483239 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature