Optimization of acquisition time and reconstruction parameters for quantitative single-photon emission computed tomography/computed tomography using iodine-123 metaiodobenzylguanidine.

ABSTRACT: This study aimed to determine the optimal measurement conditions for accurate standardized uptake value (SUV) analysis of iodine-123 metaiodobenzylguanidine (123I-MIBG) by examining the relationship between image convergence and quantitation. Single-photon emission computed tomography/computed tomography images were acquired using JS-10 and National Electrical Manufacturers Association (NEMA) body phantoms, with acquisition time per view varied (10, 30, 50, and 100 s/view). Image reconstruction was performed using three-dimensional-ordered subset expectation maximization, adjusting the product of subset and iteration (SI product; 60, 120, 180) and Gaussian filter parameters (8, 10, 12 mm). For the JS-10 phantom, we evaluated the dose linearity (DL), the recovery coefficient (RC) of individ

SUBMITTER: Tsujimoto M 

PROVIDER: S-EPMC12483245 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature