Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First-Degree Relatives of Patients With Bipolar Disorder.

ABSTRACT:

Introduction

Prior research suggests structural brain abnormalities and cognitive difficulties in patients with bipolar disorder. Although there is some evidence that similar structural and cognitive changes may also be present in unaffected relatives (UR) of patients with bipolar disorder, it is not known whether they remain static or aggravate over time. In this study, we investigate the longitudinal trajectories of cognition and brain structure in UR.

Methods

Longitudinal neurocognitive and MRI data were acquired at baseline from UR (n = 72) and healthy controls (HC; n = 65) and at 15 (±4) months follow-up (UR n = 32; HC n = 38). The differential trajectories between UR and HC in neurocognitive performance, white matter volume, regional cortical gray matter (GM) volume an

SUBMITTER: Kjærstad HL 

PROVIDER: S-EPMC12483307 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature