Sparse innervation and local heterogeneity in the vibrissal corticostriatal projection.

ABSTRACT: The density and overlap of cortical axons in the dorsolateral striatum (DLS) have suggested that striatal neurons integrate widespread information from cortical regions that are functionally related. However, in vivo, DLS neuronal responses to sensory stimuli have shown unexpectedly high selectivity, raising questions about the actual degree of convergence of functional corticostriatal projections on individual striatal cells. Here, we investigated this question by focusing on the projections from different whisker cortical columns in mice, as they overlap in the striatum and are co-active during behavior. Using ex vivo patch-clamp recordings in the DLS and glutamate uncaging for focal stimulations in the barrel cortex, we were able to map the location of presynaptic neurons to individual

SUBMITTER: Amroune K 

PROVIDER: S-EPMC12483506 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature