Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells.

ABSTRACT: Every explored environment is represented in the hippocampus by the activity of distinct populations of pyramidal cells (PCs) that typically fire at specific locations called their place fields (PFs). New PFs are constantly born even in familiar surroundings (during representational drift), and many rapidly emerge when the animal explores a new or altered environment (during global or partial remapping). Behavioral time scale synaptic plasticity (BTSP), a plasticity mechanism based on prolonged somatic action potential (AP) bursts induced by dendritic Ca²⁺/NMDA plateau potentials, was recently proposed as the main cellular mechanism underlying new PF formations (PFFs), but it is unclear whether burst-associated large somatic [Ca²⁺] transients are always necessary and/

SUBMITTER: Sumegi M 

PROVIDER: S-EPMC12483510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature