Nonlinear feedback modulation contributes to the optimization of flexible decision-making.

ABSTRACT: Neural activity in the primate brain correlates with both sensory evaluation and action selection aspects of decision-making. However, the intricate interaction between these distinct neural processes and their impact on decision behaviors remains unexplored. Here, we examined the interplay of these decision processes in posterior parietal cortex (PPC) when monkeys performed a flexible decision task. We found that the PPC activity related to monkeys' abstract decisions about visual stimuli was nonlinearly modulated by monkeys' following saccade choices directed outside each neuron's response field. Recurrent neural network modeling indicated that the feedback connections, matching the learned stimuli-response associations during the task, might mediate such feedback modulation. Further ana

SUBMITTER: Wu X 

PROVIDER: S-EPMC12483514 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature