Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies.

ABSTRACT: BACKGROUNDAntiretroviral therapy (ART) prevents HIV-1 replication but does not eliminate the latent reservoir, the source of viral rebound if treatment is stopped. Autologous neutralizing antibodies (aNAbs) can block in vitro outgrowth of a subset of reservoir viruses and therefore potentially affect viral rebound upon ART interruption.METHODSWe investigated aNAbs in 31 people with HIV-1 (PWH) on ART.RESULTSParticipants fell into 2 groups based on a high or low fraction of aNAb-resistant reservoir isolates, with most isolates being aNAb-resistant (IC50 > 100 μg/mL). Time on uninterrupted ART was associated with higher aNAb resistance. However, pharmacodynamic analysis predicted that many isolates would be partially inhibited at physiologic IgG concentrations, to the same degree as by singl

SUBMITTER: McMyn NF 

PROVIDER: S-EPMC12483561 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature