Systemic increase of AMPA receptors associated with cognitive impairment of long COVID.

ABSTRACT: Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC. Nevertheless, the underlying neural mechanisms remain poorly understood. Given the central role of synapses in brain function, investigation of synaptic molecular changes may provide vital insights into Cog-LC pathophysiology. In this study, we used [¹¹C]K-2 PET to characterize the density of AMPA receptors (AMPARs) on the post-synaptic cell surface, which are crucial synaptic components in brain signalling. Statistical parametrical mapping was used to spatially normalize and apply independent t-test for a voxel-based compariso

SUBMITTER: Fujimoto Y 

PROVIDER: S-EPMC12483584 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature