Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice.

ABSTRACT: The fetal liver is the primary site of hematopoietic stem cell (HSC) generation during embryonic development. However, the molecular mechanisms governing the transition of hematopoiesis from the fetal liver to the BM remain incompletely understood. Here, we identify the mammalian Polycomb Group protein Yin Yang 1 (YY1) as a key regulator of this developmental transition. Conditional deletion of Yy1 in the hematopoietic system during fetal development results in neonatal lethality and depletion of the fetal HSC pool. YY1-deficient fetal HSCs exhibit impaired migration and fail to engraft in the adult BM, thereby losing their ability to reconstitute hematopoiesis. Transcriptomic analysis reveals that Yy1 KO disrupts genetic networks controlling cell motility and adhesion in fetal hematopoiet

SUBMITTER: Saka S 

PROVIDER: S-EPMC12483607 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature