Circadian rhythmicity and biopsychosocial characteristics influence opioid use in chronic low back pain.

ABSTRACT: BACKGROUNDInter- and intraindividual fluctuations in pain intensity pose a major challenge to treatment efficacy, with a majority of people perceiving their pain relief as inadequate. Recent preclinical studies have identified circadian rhythmicity as a potential contributor to these fluctuations and a therapeutic target.METHODSWe therefore sought to determine the impact of circadian rhythms in people with chronic low back pain (CLBP) through a detailed characterization, including questionnaires to evaluate biopsychosocial characteristics, ecological momentary assessment (7 day e-diaries at 8:00/14:00/20:00) to observe pain fluctuations, and intraday blood transcriptomics (at 8:00/20:00) to identify genes/pathways of interest.RESULTSWhile most individuals displayed constant or variable/mix

SUBMITTER: Taccardi D 

PROVIDER: S-EPMC12483613 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature