The Cognitive Change Index in the Alzheimer's Disease Research Center setting: Self- and informant-ratings for perceived cognitive decline.

ABSTRACT:

Introduction

The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.

Methods

485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.

Results

High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with i

SUBMITTER: Abughofah Y 

PROVIDER: S-EPMC12483767 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature