Distinct patterns of association between the hemoglobin glycation index, the stress-hyperglycemia ratio, and the risk of new-onset atrial fibrillation in critically ill patients.

ABSTRACT:

Background

This study investigated the associations between two novel glycemic indices, the hemoglobin glycation index (HGI) and the stress hyperglycemia ratio (SHR), and the risk of new-onset atrial fibrillation (NOAF) in critically ill patients.

Methods

We retrospectively analyzed data from 3,882 adults in the MIMIC-IV database, with the primary outcome defined as NOAF within 7 days of intensive care unit (ICU) admission. Multivariate Cox regression and restricted cubic spline analyses were used to evaluate associations.

Results

NOAF occurred in 750 patients (19.3%). After adjustment for confounders, HGI exhibited a significant inverted U-shaped association with NOAF risk, with the highest risk in intermediate quartiles. In contrast, the SHR demonstrated a significa

SUBMITTER: Jie Q 

PROVIDER: S-EPMC12483897 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature