Uncovering differential gene expression between mtRNA-positive and -negative osteosarcoma cells: implications beyond mitochondrial function.

ABSTRACT:

Background

Long-term clinical outcomes for patients with osteosarcoma have shown little improvement over the past few decades. Identifying novel molecular targets to inhibit osteosarcoma cell growth remains an urgent challenge.

Methods

Explore the function of mtRNA in the occurrence and development of osteosarcoma utilizing bioinformatics analysis of the Gene Expression Omnibus (GEO) microarray dataset. The Network Analyst tool was used to analyze GSE73120. Differentially expressed genes (DEGs) were identified using GEO2R and analyzed using NetworkAnalyst. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed using Metascape and WebGestalt. A protein-protein interaction (PPI) network was constructed through the STRING databa

SUBMITTER: Meng X 

PROVIDER: S-EPMC12483910 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature