Enhancing post-operative hypothyroidism treatment: rat thyroid autotransplantation into a pre-vascularized, retrievable cell pouch™ device.

ABSTRACT:

Introduction

To overcome the limitations of lifelong hormone replacement therapy for post-operative hypothyroidism, we propose autologous thyroid transplantation into the Cell Pouch™ (CP), an implantable and retrievable medical device that supports vascularization and a homeostatic environment for cell grafting. The CP is currently in clinical trials for islet transplantation in type-1 diabetes, demonstrating its capacity to support long-term graft viability. Here, we apply the CP for thyroid tissue transplantation, leveraging the natural gland's regulatory capabilities to benefit patients unresponsive to hormone therapy. Building on previous research validating CP's support for human thyroid grafts in a mouse model, this study evaluates its therapeutic potential in a rat model mim

SUBMITTER: Memarnejadian A 

PROVIDER: S-EPMC12483921 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature