Intestinal SURF4 in dyslipidaemia and female-specific metabolic disorders: insights from rats with polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and metabolic disturbances, including dyslipidaemia. Recent studies have suggested that intestinal surfeit locus protein 4 (SURF4) contributes to elevated serum PCSK9 levels and subsequent lipid accumulation, with evidence of sex-specific differences in its expression and regulatory effects. This study aimed to investigate the involvement of intestinal SURF4 in the pathogenesis of PCOS and its potential contribution to metabolic lipid disturbances, as well as to explore lipid-PCOS associations through Mendelian randomization (MR) analysis.

Methods

This research established two rat models of PCOS: one by administering letrozole in combination w

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12483925 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature