An integrative multi-omics analysis of histone modifications and DNA methylation reveals the epigenomic landscape in apple under drought stress.

ABSTRACT: Epigenetic regulation plays a key role in plant development and stress response processes. Although previous studies have found that epigenetic modifications are involved in the drought response in apple, a comprehensive epigenomic profile of the response of apple to drought is needed. To characterize epigenomic profiles during the response of apple to drought, we conducted transcriptome, whole-genome bisulfite sequencing, and ChIP-seq analyses of six histone modifications (H3ac, H3K9ac, H3K14ac, H3K4me3, H3K27me3, and H3K36me3) in Malus hupehensis at 0, 3, 6, and 9 days after drought treatment. The greatest changes in differentially expressed genes were observed after 6 days of drought treatment. However, the highest levels of DNA methylation near the gene region were observed after only

SUBMITTER: Wang S 

PROVIDER: S-EPMC12483960 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature