The N gene protects tomato plants from tomato brown rugose fruit virus infection.

ABSTRACT: The tobamovirus tomato brown rugose fruit virus (ToBRFV) has recently emerged, causing significant damage to the tomato industry in various regions worldwide, including the US. ToBRFV evades the widely used Tm-2² resistance gene, which encodes a nucleotide-binding leucine-rich repeat (NLR) class immune receptor with an N-terminal coiled-coil (CC) domain that confers resistance to the tomato mosaic virus (ToMV). In this study, we tested a transgenic tomato line (tomato^NN) expressing the Nicotiana glutinosa N gene, which encodes an NLR with a Toll-Interleukin 1 homology domain (TIR) at the N-terminus, for resistance to ToBRFV. Our results demonstrate that tomato^NN is resistant to ToBRFV, evidenced by the necrotic local lesions observed on the inoculated leave

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12483991 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature