Serum creatinine to cystatin C ratio is a prognostic indicator in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy.

ABSTRACT:

Background

This study aimed to explore the relationship between pretreatment serum creatinine to cystatin C ratio (CCR) and prognosis in patients with esophageal squamous cell carcinoma (ESCC) receiving neoadjuvant immunochemotherapy (NICT).

Methods

Two hundred and two ESCC patients who received NICT were included in the current retrospective study. The restricted cubic spline displayed the non-linear relationship between prognosis and CCR. The association between overall survival (OS)/disease-free survival (DFS) and CCR was also investigated. Kaplan-Meier methods and Cox proportional hazard regression analyses were employed.

Results

The connection between DFS/OS and CCR suggested that their interaction was non-linear. The restricted cubic spline (RCS) model identifie

SUBMITTER: Feng J 

PROVIDER: S-EPMC12484131 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature