Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immunotherapies.

ABSTRACT:

Objectives

Preclinical models that accurately recapitulate the human immune response, particularly within the tumor microenvironment (TME), are needed for the translational and predictive testing of new therapies. Here, we examine whether the genO-BRGSF-HIS model-characterized by robust reconstitution of both human lymphoid and myeloid cells following engraftment with CD34⁺ cord blood cells-could be a translatable mouse model for human tumor biology and a relevant platform for evaluating novel immunotherapies.

Methods

genO-BRGSF mice were reconstituted with human CD34⁺ cord blood cells (genO-BRGSF-HIS) and treated with exogenous human Flt3 ligand (hFlt3L). Myeloid and dendritic cell functionality was analyzed following treatment with different compounds

SUBMITTER: Martin GH 

PROVIDER: S-EPMC12484184 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature