Drug-induced agranulocytosis: a disproportionality analysis and umbrella review.

ABSTRACT:

Background

Drug-induced agranulocytosis (DIA) is a rare but life-threatening hematologic disorder that demands increased clinical and research attention. This study aimed to provide the current overview of DIA for clinical guidance.

Methods

Using real-world data from FDA Adverse Event Reporting System (FAERS), we performed a disproportionality analysis to identify the drugs associated with agranulocytosis, employing the information component and reporting odds ratio algorithms. Logistic analysis was conducted to explore the confounding factors of DIA. Time-to-onset analysis was implemented to compare the adverse event onset time among different drugs. To comprehensively supplement and corroborate our disproportionality findings, we further conducted an umbrella review of sys

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12484221 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature