Clinical laboratory analytes and platelet-associated parameters as surrogate markers of subclinical inflammation in latent tuberculosis infection.

ABSTRACT:

Background

The global burden of latent tuberculosis infection (LTBI), with one-third of the population, poses a significant challenge in the diagnosis and treatment of TB. Household contacts (HHCs) of active TB-infected individuals are one of the major high-risk groups for whom early screening and timely intervention are highly critical to interrupt TB transmission. The subclinical latent infection transitions into active TB disease due to multiple factors. Laboratory diagnostic markers inherent to interferon-gamma release assay (IGRA) positive and negative HHCs may help predict the risk of LTBI and subsequent reactivation. The study aims to identify biochemical and hematological diagnostic markers associated with HHCs and their IGRA status, and to explore the likelihood of clinica

SUBMITTER: Selvavinayagam ST 

PROVIDER: S-EPMC12484228 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature