Malignancy and Autoimmune Susceptibility in Adult Patients with Human Inborn Errors of Immunity.

ABSTRACT: Inborn errors of immunity (IEI) are a heterogeneous group of genetic disorders that disrupt the normal development and function of the immune system. These diseases not only increase susceptibility to infections but also significantly elevate the risk of developing malignancies and autoimmune diseases. The interplay between immune dysregulation, chronic inflammation, and altered cellular homeostasis in IEI can lead to aberrant cellular proliferation and self-reactive immune responses. Malignancy in IEI often arises due to the immune system's failure to effectively eliminate transformed cells, predisposing patients to lymphomas, leukemias and solid tumors. Autoimmune diseases in IEI can result from defective T-regulatory cell function, impaired central or peripheral tolerance mechanisms or

SUBMITTER: Segura-Tudela A 

PROVIDER: S-EPMC12484250 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature