Emergence of livestock-associated MRSA in the Egyptian Nile Delta that carry the exfoliative toxin gene etA: a case for enhanced surveillance.

ABSTRACT:

Background

Staphylococcus aureus is a common opportunistic pathogen. Methicillin-resistant strains, MRSA, carry SCCmec elements that include beta-lactam resistance genes mecA/mecC. One globally common lineage, Clonal Complex (CC) 15 failed to evolve MRSA until, in 2016, CC15-MRSA were described from Saudi Arabia that carried a SCCmec V element also comprising the fusidic acid resistance gene, fusC. Henceforth, this strain has spread across Gulf states and Egypt infecting or colonizing both, humans and livestock.

Methods

DNA-microarray-based typing was performed on 134 MRSA isolates collected from livestock and farmers in the Nile Delta region of Egypt in 2022. Isolates with conspicuous toxin gene carriage were sequenced applying Oxford Nanopore Technology.

Results

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SUBMITTER: Monecke S 

PROVIDER: S-EPMC12484256 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature