Effects of habitual endurance and resistance exercise on insulin action in primary human skeletal muscle stem cells.

ABSTRACT: Endurance-oriented exercise typically enhances insulin action in skeletal muscle; however, relatively little is known about the impact of resistance exercise. In the present study, insulin action was determined in primary human skeletal muscle stem cells (HSkMCs) isolated from habitual endurance and resistance exercisers and sedentary controls (N = 8-9/group). Insulin action was assessed by insulin-stimulated glycogen synthesis and glucose oxidation using 14C-labeled glucose and insulin signal transduction measured as phosphorylation of Akt (Ser⁴⁷³) and AS160 (Thr⁶⁴⁰). No differences were detected in basal and insulin-stimulated glycogen synthesis, glucose oxidation, and insulin signal transduction between the endurance and resistance exercisers. When HSkMCs were chal

SUBMITTER: Krassovskaia P 

PROVIDER: S-EPMC12484306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature