Voxel-wise analysis of brain metastasis predilection sites in breast cancer by clinical features.

ABSTRACT:

Purpose

Brain metastases (BMs) occur in 15-30% of breast cancer patients, particularly in HER2-positive and triple-negative(TN) subtypes, and signify poor prognosis. This study aimed to identify vulnerable BM locations through voxel-wise analysis of clinical characteristics.

Method

We retrospectively analyzed 161 breast cancer patients with BMs (2007-2019) and performed voxel-wise MRI analysis using standardized templates. Segmentation results were superimposed on standard brain templates to construct stereo-specific frequency thermograms and compared under the same voxel. Two-tailed Fisher's exact test was performed. Overall survival (OS) and post-progression survival (PPS) after confirmation of brain metastases were tested by Kaplan-Meier, Cox regression analysis calculati

SUBMITTER: Wang H 

PROVIDER: S-EPMC12484462 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature