Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma.

ABSTRACT:

Objective

Glioblastoma (GBM) is a highly aggressive brain tumor with complex immune microenvironment and molecular heterogeneity. This study aimed to characterize immune infiltration patterns and identify prognostic biomarkers in GBM.

Methods

We classified GBM samples using immune-related gene sets and correlated subtypes with molecular features. Key genes were identified through Cox and LASSO regression analyses. Multi-omics approaches including single-cell RNA sequencing, transcriptional network analysis, and molecular docking were employed to investigate therapeutic targets.

Results

Two immune subtypes (c1/c2) were identified, with c2 showing mesenchymal features and poorer prognosis. Four immune-related genes (RPL39L, AEBP1, EFEMP2, GALNT12) were prognostic marker

SUBMITTER: Yin Y 

PROVIDER: S-EPMC12484469 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature