Molecular phylogeny of the Pseudallescheria boydii species complex: proposal of two new species.

ABSTRACT: Pseudallescheria boydii (anamorph Scedosporium apiospermum) is the species responsible for human scedosporiosis, a fungal infection with a high mortality rate and which is difficult to treat. Recently, it has been demonstrated that high genetic variation exists within this species. We have performed a morphological and molecular study involving numerous strains of clinical or environmental origins and from different countries. The analysis of partial sequences of the beta-tubulin (two loci) and calmodulin genes and the internal transcribed spacer region of the rRNA gene has demonstrated that P. boydii is a species complex. The combined analysis of the sequences of the four loci of 60 strains has showed the presence of 44 haplotypes in the in group. Three species morphologically related to

SUBMITTER: Gilgado F 

PROVIDER: S-EPMC1248451 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature