Attenuation of malignant phenotype of glioblastoma following a short course of the pro-oxidant combination of Resveratrol and Copper.

ABSTRACT:

Background

We investigated a novel therapeutic approach to glioblastoma (GBM) that targets cell-free chromatin particles (cfChPs) that are released from dying GBM cells and aggravate the oncogenic phenotype of living GBM cells. cfChPs can be deactivated by oxygen radicals (OR) generated upon oral administration of the nutraceuticals Resveratrol (R) and Copper (Cu).

Methods

Ten patients with glioblastoma awaiting surgery were administered 5.6 mg of Resveratrol (R) and 560 ng of Copper (Cu) four times a day for an average of 11.6 ± 5.37 days. Another ten patients who did not receive R-Cu acted as controls. A tissue sample was taken at operation for analysis.

Results

R-Cu treatment led to marked deactivation of cfChPs that were present in the tumour microenvironment, whi

SUBMITTER: Bandiwadekar C 

PROVIDER: S-EPMC12484550 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature