GLRX2 polymorphism and oxidative stress levels impact urothelial bladder cancer outcomes.

ABSTRACT: The bladder is continuously exposed to oxidative and mutagenic agents. Such chemicals are metabolized, filtered by the kidneys, and excreted in the urine. Not surprisingly, urothelial bladder cancer (UBC) is the 9th most common cancer worldwide. This study investigates whether the C > T (rs912071) polymorphism in the Glutaredoxin 2 (GLRX2) gene, oxidative stress marker levels, and GLRX2 expression are associated with prognosis and recurrence in 341 patients with UBC. Gene expression data were compared to those available in TCGA. The TT genotype (OR = 2.475, p = 0.017) was positively associated with the risk of 1-year recurrence. Hypertensive patients carrying the CT genotype presented a reduced risk for recurrence (OR = 0.460, p = 0.047) and high-grade tumors (OR = 0.188, p = 0.001). Lipid

SUBMITTER: Silva IM 

PROVIDER: S-EPMC12484609 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature