Network analysis of gene expression reveals regulators of cell viscosity and mechanical phenotype.

ABSTRACT: Cell mechanical properties, such as cell stiffness and viscous behavior, have been proposed as biomarkers of cell disease states. Moreover, the molecular pathways that modify cell mechanics may also be potential novel targets for managing lethal diseases, such as cancer, by specifically changing the mechanical phenotype of cells along with the associated functional phenotype. This study explores the relationship between the viscosity and stiffness of cells and the underlying molecular mechanisms. We used a large linked molecular dataset to explore the correlations between gene expression, cell migration, and cell mechanical properties, which were quantified by two viscous rate constants from a standard linear solid viscoelasticity model and apparent Young's modulus from a Hertzian contact

SUBMITTER: Young KM 

PROVIDER: S-EPMC12484610 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature