Colistin adorned topical nanoemulsion gel formulation for enhanced anti-microbial activity.

ABSTRACT: The rising prevalence of severe skin infections, particularly those linked to multidrug-resistant (MDR) bacteria, poses an increasing public health challenge. Although the systemic administration of broad-spectrum antibiotics such as colistin sulfate (CS) represents a last-resort treatment for these infections, its use is associated with serious, life-threatening damage to vital organs. The current investigation aimed to develop and assess the efficacy of a CS-loaded nanoemulgel (NEG) as an anti-microbial therapy. Initially, a nanoemulsion (NE) was prepared using high speed homogenization, employing Labrafil as oil, Tween 80 as the surfactant and Transcutol as the co-surfactant. The formulation was then characterized for its pH, thermodynamic stability, particle size, drug content and entr

SUBMITTER: Ijaz F 

PROVIDER: S-EPMC12484695 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature