Field outbreak investigation and immunoinformatic analysis suggest potential immune evasion by Newcastle disease virus Sub-Genotype XIV.2 in Nigeria.

ABSTRACT: Poultry production is one of the fastest-growing agricultural sub-sectors in Nigeria. However, it faces numerous challenges, mainly from frequent Newcastle disease (ND) outbreaks even in vaccinated flocks, causing huge economic losses. The recurring outbreaks raise concerns about the efficacy of ND vaccine and the need to understand the immunomodulatory mechanism of the ND virus (NDV). This study investigated a recent outbreak of NDV that resulted in 95% mortality in a vaccinated broiler parent stock in Nigeria by utilizing immunoinformatic tools to elucidate the possible immune evasion features of the disease-causing NDV. Genetic analysis of the complete fusion gene showed that the NDV isolate belong to sub-genotype XIV.2, a virulent strain prevalent in Nigeria. Predicted immunogenic pept

SUBMITTER: Sajo MU 

PROVIDER: S-EPMC12484761 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature