Affordable ultrasensitive electrochemical detection of PCA3 for early prostate cancer diagnosis.

ABSTRACT: Prostate cancer frequently goes undetected at its early stage and it's a major concern in the male population. To address this challenge, we provide a new approach based on electrochemical biosensing for the efficient detection of prostate cancer using PCA3 DNA biomarkers. Screen-printed paper electrodes were fabricated and modified with gold graphene quantum dots (Au-GQD), which were synthesized by an established domestic microwave method. Au-GQD, with their unique properties, find applications in various fields, including sensing, biomedicine, and catalysis, due to their enhanced catalytic activity, biocompatibility, and optical properties. Further, a PCA3 probe DNA was immobilized and characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The develope

SUBMITTER: Raj D 

PROVIDER: S-EPMC12484813 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature