The xIV-LDDMM toolkit of image-varifold based technologies for mapping 3D images and spatial-omics across scales.

ABSTRACT: Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose numerous challenges to integrating data with reference coordinate systems and across scales. This paper describes a collection of technologies that we have developed for mapping data across scales and modalities, such as genes to tissues, specifically in a 3D setting. Our collection of technologies include (i) an explicit censored data representation for the partial matching problem mapping whole brains to subsampled subvolumes, (ii) a multi, scale-space optimization technology for generating resampling grids optimized to represent spatial geometry at fixed complexities

SUBMITTER: Stouffer KM 

PROVIDER: S-EPMC12484866 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature