Systematic review and network meta-analysis comparing the efficacy of conventional therapy and biologics to prevent endoscopic postoperative recurrence in patients with Crohn's disease.

ABSTRACT:

Background

As no direct comparison is available between drugs to prevent endoscopic postoperative recurrence (POR) in Crohn's disease (CD), hierarchizing these therapeutic options remains challenging.

Objectives

We aimed to compare the effectiveness of treatments to prevent CD endoscopic POR.

Design

Systematic review and network meta-analysis using a random-effects model.

Data sources and methods

We include studies comparing treatments to prevent CD POR according to PRISMA guidelines. The primary endpoint was endoscopic POR (Rutgeerts score ⩾i2). Surface under the cumulative ranking (SUCRA) was used to hierarchize the treatments.

Results

Twenty studies were included (2414 patients). Overall heterogeneity was moderate (τ = 0.34). Ustekinumab (odds ratio (

SUBMITTER: Hupe M 

PROVIDER: S-EPMC12484893 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature