Flexible value coding in the mesolimbic dopamine system depending on internal water and sodium balance.

ABSTRACT: Homeostatic imbalances elicit strong cravings, such as thirst and salt appetite, to restore equilibrium. Although midbrain dopaminergic neurons are known to encode the value of foods, their nutritional state-dependency remains unknown. Here, we show that the activity of the dopaminergic mesolimbic pathway flexibly expresses the positive and negative values of water and salt depending on the internal state in mice. Mice showed behavioral preference and aversion to water and salt depending on their internal water and sodium balance. Fiber photometry recordings revealed that dopamine neurons in the ventral tegmental area and dopamine release in the nucleus accumbens core flexibly showed bidirectional excitatory and inhibitory responses to water and salt intake in a state-dependent manner. Fur

SUBMITTER: Ozawa T 

PROVIDER: S-EPMC12484953 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature