Impact of epstein-barr virus reactivation on cytokine levels in pregnant women with malaria in the west region of cameroon.

ABSTRACT: We have previously reported that pregnant women with EBV reactivation are more prone to severe malaria than those with latent EBV. This suggests that lytic reactivation of EBV is strongly associated with malaria severity and could be investigated as a risk factor for severe malaria during pregnancy. To understand the association between EBV reactivation and malaria severity, we investigated the levels of IL-6, IFN-γ, TNF-α, IL-10, and TGF-β in pregnant women with malaria and reactivated EBV vs. latent EBV. A total of 220 pregnant women were recruited from three hospitals in the West region of Cameroon. Malaria was diagnosed by microscopy and Nested PCR, while EBV reactivation was assessed by detecting EBV nuclear antigen IgG, viral capsid antigen IgM, and early antigen IgG using ELISA. Cyt

SUBMITTER: Chatue IAD 

PROVIDER: S-EPMC12485065 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature