MFSD12, transcriptionally regulated by PLAGL2, promotes bladder cancer progression.

ABSTRACT: Bladder cancer (BLCA) is one of the most common malignant tumors of the urinary system. Identification of novel molecular signaling targets for the tumorigenesis of BLCA is important. Data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases suggest that major facilitator superfamily domain containing 12 (MFSD12) may act as an important oncogene in BLCA. MFSD12 expression is confirmed to be elevated in BLCA patients. Genetic manipulation of MFSD12 mediated by Tet-inducible lentiviral expression vector is conducted in two BLCA cell lines, including UMUC3 and 5637. Following this manipulation, the cells are subjected to treatment with or without doxycycline. Our results show that MFSD12 knockdown inhibits cell proliferation, migration, and invasion, and arrests

SUBMITTER: He J 

PROVIDER: S-EPMC12485097 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature