Metabonomics of serum bile acids in patients with pre-eclampsia.

ABSTRACT: Pre-eclampsia remains a leading contributor to maternal and perinatal mortality, particularly in resource-limited settings, prompting the urgent search for accessible early biomarkers. Capitalising on growing evidence that bile-acid dysregulation participates in hypertensive disorders of pregnancy, we conducted a case-control study in which fasting serum from 30 women with preeclampsia and 30 gestational-age-matched healthy pregnant controls was subjected to targeted LC-MS/MS quantification of 59 bile-acid subtypes after DMED derivatisation. 30 analytes differed significantly (unpaired t-test, FDR-adjusted q-value < 0.05; fold-change ≥ 2), with glycochenodeoxycholic acid (GCDCA) achieving an AUC of 0.879 (95% CI 0.782-0.946). A two-metabolite panel comprising GCDCA and glycodeoxycholic aci

SUBMITTER: Su J 

PROVIDER: S-EPMC12485204 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature