Comparison of Apixaban With Warfarin in Patients on Dialysis Within an Integrated Health Care System.

ABSTRACT:

Introduction

The risk and benefit for patients on dialysis receiving anticoagulation (AC) therapy have not been clearly established. This study aimed to compare the rates of clinically significant thrombotic and bleeding events in patients on dialysis.

Methods

This is a retrospective cohort study conducted using Kaiser Permanente Northern California's electronic medical record database from 2013 to 2021. Patients over 18 years old on dialysis who were prescribed warfarin or apixaban were included. Patients with mechanical valves were excluded. The outcomes were analyzed using Mann-Whitney tests for continuous variables, χ² tests for categorical variables, and Kaplan-Meier method for time-to-event analysis.

Results

In the study period, 9832 patients were not

SUBMITTER: Shaheed T 

PROVIDER: S-EPMC12485249 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature