Muscle Abnormalities in Nonhospitalised Patients With Post-COVID-19 Condition.

ABSTRACT:

Background

Post-COVID condition (PCC) affects ~10% of SARS-CoV-2-infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the skeletal muscle of these patients and compare them with healthy controls.

Methods

Biopsies were obtained from the vastus lateralis muscle of 28 nonhospitalised PCC patients without concomitant diseases (75% women, mean age 46.4 ± 10.4 years) and 28 age- and sex-matched healthy controls (79% women, mean age 46.6 ± 8.7 years). The analysis included morphological and pathological alterations, fibre type composition, fibre cross-sectional area, capillarisation, number of myonuclei, presence of developmental myosin, CD68⁺ cells, macroautophagy markers, mitocho

SUBMITTER: Tryfonos A 

PROVIDER: S-EPMC12485287 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature